Astapiana Villa Giusso was first mentioned, under the ancient name of Astichiano, in 1578 by Monsignor Sacra, who, in his apostolic report, lamented the state of ruin of the ancient church of S. Maria in Jerusalem, likely of Angevin-Aragonese origin. This particularly evocative place was inhabited since Roman times and was most likely one of the numerous hillside hamlets scattered throughout the area during the Angevin-Aragonese period.

At the beginning of the 17th century, the area of Vico Equense was chosen for the construction of a Camaldolese monastery. In 1604, the complex was built thanks to the generosity of Matteo di Capua, Prince of Conca and feudal lord of Vico Equense, who donated the necessary land, and Cesare Zaffarano, who provided a substantial bequest to the Camaldolese. Twelve cells for monks and two guesthouses were built, one of which was notably large and distinguished by its majolica-tiled kitchen. Additionally, a double boundary wall was constructed, featuring two small towers. The monastery was inhabited by hermits until 1807, when Joseph Bonaparte, then King of Naples, suppressed religious orders and seized their properties. In 1815, after his defeat against Austria, Joachim Murat took refuge there for several days.

The complex remained part of the royal properties until 1822, when it was purchased by Duke Luigi Giusso, a Genoese banker, who established an experimental production for the kingdom: silkworm farming. The latter had an excellent start due to the healthiness of the location, but after several decades had to be abandoned following an epidemic that decimated the silkworms and eliminated this type of farming from the Sorrento peninsula.

The Duke then abandoned his innovative pursuits and transformed the guesthouse into a summer residence, a function it maintained throughout the twentieth century. Since then, the site has acquired its current name, Astapiana Villa Giusso.

Various generations of the Giusso family have succeeded one another, and the current descendants directly manage the estate.